Naltrexone and naloxone are two medications that often come up in discussions surrounding addiction treatment and opioid overdose response. Both drugs belong to the class of opioid receptor antagonists, which means they work by blocking the effects of opioids in the brain. While they share some similarities, their uses, mechanisms, and effects differ significantly. Understanding the distinctions between naltrexone and naloxone is crucial for healthcare professionals, patients, and families affected by substance use disorders. The opioid epidemic has made the need for effective treatment options and emergency responses more urgent than ever. As communities strive to combat addiction and reduce the number of opioid-related deaths, these two medications play vital…