Azithromycin and erythromycin are two widely used antibiotics that belong to the macrolide class of medications. They are both effective in treating various bacterial infections by inhibiting bacterial protein synthesis, which ultimately leads to the death of the bacteria. Both drugs are commonly prescribed for respiratory tract infections, skin infections, and certain sexually transmitted infections, among others. Despite their similarities, there are significant differences between the two that can influence a physician’s choice of treatment. In clinical practice, understanding these differences is essential for selecting the appropriate antibiotic that will effectively target the infection while minimizing potential side effects. Factors such as bacterial resistance, patient tolerance, and specific infection types…