Fluconazole and ketoconazole are two antifungal medications widely used in the treatment of various fungal infections. They belong to a class of drugs known as azoles, which work by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. This disruption leads to the weakening and eventual death of the fungus. While both medications are effective in treating a range of fungal infections, they differ in terms of their spectrum of activity, pharmacokinetics, and clinical applications. Understanding these differences can help healthcare providers make informed decisions when prescribing antifungal therapies. As the prevalence of fungal infections continues to rise, particularly among immunocompromised individuals, the choice between fluconazole and…