Ondansetron and Metoclopramide are two medications commonly used to manage nausea and vomiting, conditions that can arise from various causes including chemotherapy, surgery, and gastrointestinal disorders. Both drugs serve important roles in clinical practice, yet they operate through different mechanisms of action and have unique side effect profiles. Understanding their differences, indications, and effectiveness is crucial for healthcare providers and patients alike. Nausea and vomiting can significantly impact a person’s quality of life, making effective treatment essential. Ondansetron, a selective serotonin 5-HT3 receptor antagonist, primarily works by blocking the action of serotonin, a neurotransmitter that can trigger nausea. On the other hand, Metoclopramide is a dopamine receptor antagonist that also…